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701048 Cellular and Molecular Biology of Cancer : Therapeutic Implications

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701048 Cellular and Molecular Biology of Cancer

Task:

You will have to provide a detailed and integrated description of key signalling pathways and/or cellular components relevant to the topic and hallmarks covered by the questions, using clear examples, as well as discuss any therapeutic implications. Please support your essays using relevant literature.
Group 1
1. Critically evaluate how defects in DNA repair and DNA replication fidelity are linked with genomic instability, using examples.
2. With reference to lung cancer and breast cancer, critically evaluate the roles and activity of specific oncogenes and tumour suppressors within each type of cancer and within molecular subsets of each cancer
Group 2
1. Critically discuss the role of hypoxia in the regulation of the metabolic switch in cancer, highlighting the key factors and pathways involved in this process.
2. Critically compare active and adoptive immunotherapies, including detailed mechanisms of action with implications for immunoevasion, current applications, advantages, and limitations
Group 3
1. Critically discuss how advancements in cancer detection and diagnostic biomarkers are saving lives, using examples
2. Critically evaluate the proposal that ‘genetic damage is the match that lights the fire of malignancy, and inflammation is the fuel that feeds the flames.’ Your answer should include the key cellular and molecular mechanisms involved in the initiation and progression of cancer, and examples of repetitive inflammatory stimuli linked to specific subtypes of cancer.

701048 Cellular and Molecular Biology of Cancer

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