Materials Review the following materials from this week’s readings before working on this

Materials Review the following materials from this week’s readings before working on this case study.
Michigan Quality Improvement Consortium. (2014, May). Statin dose intensity and equivalency chart (PDF). UMHS Lipid Therapy Guideline.
American Heart Association. (2018, December 10). Statins have low risk of side effects: American Heart Association scientific statement.
Complete this simple chart to help you answer the case study questions. Highlight the correct answers or delete the incorrect answers in each column.
Drug Class
Side Effect
Best for:
Fibric acid derivatives (fibrates)
Muscle aches
Rhabdomyolysis
GI symptoms
Gallstones
Constipation
Increased blood glucose
Headache
Affects warfarin levels
LDL
TG
Pregnancy
Liver disease
CV risk reduction
Bile acid sequestrants (BAS)
Muscle aches
Rhabdomyolysis
GI symptoms
Gallstones
Constipation
Increased blood glucose
Headache
Affects warfarin levels
LDL
TG
Pregnancy
Liver disease
CV risk reduction
HMG-CoA reductase inhibitors
(Statins)
Muscle aches
Rhabdomyolysis
GI symptoms
Gallstones
Constipation
Increased blood glucose
Headache
Affects warfarin levels
LDL
TG
Pregnancy
Liver disease
CV risk reduction
Case Information Mr. Jones, a 65-year-old white male with a history of HTN and diabetes mellitus, has the following lab results:
Lab
Results
Total Cholesterol
210 mg/dL
LDL
130 mg/dL
HDL
28 mg/dL
Triglycerides
323 mg/dL
Questions to Answer Note for students: Type your answers in-line with each question.
What drug class is most important to prescribe for Mr. Jones’ abnormal lipids?
Answer:
If Mr. Jones’ triglycerides were 600, would an additional antilipidemic be indicated? If so, from what drug class? Are these 2 classes okay to combine?
Answer:
What other drug classes would you look for on Mr. Jones’ medication list that can cause elevated triglycerides?
Answer:
How do the three antilipidemic classes work differently? Which can NOT be taken together?
Answer:
What would you teach Mr. Jones about statins?
Answer:
Mr. Jones calls and tells you that he heard from a friend that statins cause muscle aches and that he can no longer take statins if he gets muscle aches. He feels like he might have a few more muscle aches than normal.
Can Mr. Jones still take statins, or does he need to switch to another class of antilipidemics?
Answer:
What labs might you check to confirm whether he is having this side effect?
Answer:
What kind of reassurance can you give Mr. Jones?
Answer:
Answer these additional questions:
What is the difference between a low-intensity, moderate-intensity, and high-intensity statin? What level are most statins?
Answer:
What are the two specific HMG-CoA reductase inhibitor drugs that are considered high potency statins?
Answer:
Which two specific HMG-CoA reductase inhibitor drugs have the least side effects?
Answer:
Which of the antilipemic classes is most effective and recommended as first line treatment by AHA/ACC for most people?
Answer:
Which antilipidemic class is NOT appropriate in pregnancy?
Answer:
For what patients would you consider bile acid sequestrants (BAS)?
Answer:
What are the most common side effects with BAS?
Answer:
References

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